Research

The following is a compilation of some of the most important research in support of the Bale/Doneen method and the oral systemic practice assumptions.

1

Bale/Doneen causal relationship article 

2

Periodontal pathogen AA  and its effects on endothelial cells

3

Changes in clinical and microbiological periodontal profiles relate to progression of carotid intima-media thickness

4

Associations between chronic periodontitis/edentulism and risk of coronary heart disease

5

Concordia study showing lower healthcare cost across the board for patients under periodontal maintenance

6

Periodontal disease and Lp-Pla2 inflammatory biomarkers

7

Periodontal disease and stroke risk

8

Periodontal disease associated with heart attack risk

9

Oral infections and vascular disease study (INVEST)

10

Periodontal disease and coronary plaque

11

Oral pathogens in acute coronary syndrome thrombi

12

Periodontal pathogens in carotid atheroma

13

 Periodontal pathogen (Pg) invasion of heart cells and endothelial cells

14

 Microbiological parameters in patients with acute myocardial infarction

15

Periodontal disease and inflammation

16

Periodontology and Caridiology consensus report

17

Periodontitis increases risk of first myocardial infarction

18

Periodontal therapy and regression of carotid IMT score

19

Coronary heart disease and tooth loss

20

Oxidative stress and oral bacteria

21

Periodontal disease and pancreatic cancer 

22

Periodontal disease and obstructive sleep apnea 

23

Periodontal disease and breast cancer

24

Periodontal pathogen (Pg) and esophageal cancer

25

Oral pathogens disrupt immune response

26

Periodontal disease and lung cancer

27

28

29

30

31

32

33

34

35

36

37

38

39

Periodontal disease and chronic kidney disease

Periodontal pathogen (Pg) and arthritis

Periodontal pathogens, osteoarthritis and periprosthetic infections of knee

Periodontal disease and diabetes

Periodontal disease and low birth weight risk

Periodontal disease and cognitive decline in Alzheimer's patients

Periodontal disease, cognitive impairment, and dementia

Periodontal disease treatment lowers cancer risk

Periodontal disease and venous thromboembolic disease

Periodontal pathogens in coronary atherosclerotic plaque 

Periodontal pathogen (Pg) interactions with human coronary artery endothelial cells 

Oral bacteria found in 90% of unhealthy heart valves 

Periodontal disease and pre-hypertension/hypertension 

40

Periodontal pathogens linked to low HDL and high triglycerides 

41

Periodontal pathogens in carotid atheroma 

42

Cardiovascular and cerebrovascular disease secondary to oral infection

43

Glomerulonephritis secondary to oral infection 

44

Bacterial endocarditis secondary to oral infection

45

Periodontal pathogen (Pg) is the most abundant species detected in coronary and femoral arteries.

46

Periodontal pathogen (Pg) is involved in the pathogenesis of diabetes mellitus (DM).

47

Periodontal pathogen increases colorectal cancer mortality

48

High Lp-PLA2 doubles risk for Alzheimers

49

Periodontal pathogens and oxidative stress

50

Periodontal pathogens and rheumatoid arthritis

51

The use of phase contrast microscopy is useful in periodontal risk assessment

52

The use bleach as an oral antimicrobial

53

History of periodontitis, diagnosis and edentulism as predictors of cardiovascular disease, stroke, and mortality in postmenopausal women

54

Links between oral health and general health: The case for action

55

CANTOS study on targeting inflammation

56

Periodontal disease and atherosclerosis: Strengthening the oral-systemic link.

57

Mouth Bacteria Linked To Esophageal Cancer

58

Research May Explain Why Gum Disease Is Linked To Heart Disease

59